GLP-1 Medications: Every US Brand and What It Is
GLP-1 medications list: semaglutide, tirzepatide, liraglutide, dulaglutide and oral pills — brands, approved uses and how they differ. Not medical advice.
Anonymous user report. Not medical advice. Peptides discussed are not FDA-approved for the uses described. Editorial process →
Short answer
GLP-1 receptor agonists mimic the gut hormone GLP-1 to raise insulin when glucose is high, slow stomach emptying and reduce appetite. US-approved options: semaglutide — Ozempic (type 2 diabetes injection), Wegovy (weight management injection), Rybelsus (diabetes tablet) and the Wegovy pill (weight management tablet); tirzepatide, a GLP-1/GIP dual agonist — Mounjaro (diabetes) and Zepbound (weight management); liraglutide — Victoza (diabetes) and Saxenda (weight management), daily injections with generics available; dulaglutide — Trulicity (diabetes); and orforglipron — Foundayo, a non-peptide daily pill for weight management approved in 2026. Pipeline drugs such as retatrutide, CagriSema, MariTide and survodutide are not approved. A prescriber decides which, if any, fits. Peptide Confessions does not publish dosing, timing, injection or sourcing guidance.
Every US GLP-1 brand at a glance
Last reviewed October 15, 2026.
| Brand | Molecule | Form | US approved use | Generic? |
|---|---|---|---|---|
| Ozempic | Semaglutide | Weekly injection | Type 2 diabetes; cardiovascular and kidney risk | No |
| Wegovy | Semaglutide | Weekly injection | Weight management; cardiovascular risk | No |
| Wegovy pill | Semaglutide | Daily tablet | Weight management | No |
| Rybelsus | Semaglutide | Daily tablet | Type 2 diabetes | No |
| Mounjaro | Tirzepatide (GLP-1 + GIP) | Weekly injection | Type 2 diabetes | No |
| Zepbound | Tirzepatide (GLP-1 + GIP) | Weekly injection | Weight management; sleep apnoea | No |
| Victoza | Liraglutide | Daily injection | Type 2 diabetes | Yes |
| Saxenda | Liraglutide | Daily injection | Weight management | Yes |
| Trulicity | Dulaglutide | Weekly injection | Type 2 diabetes | No |
| Foundayo | Orforglipron (non-peptide) | Daily pill | Weight management | No |
How they differ
Molecule: semaglutide, liraglutide and dulaglutide act only on the GLP-1 receptor; tirzepatide also acts on GIP, and in head-to-head trials produced more weight loss than semaglutide (Mounjaro vs Ozempic). Frequency: daily (liraglutide, oral pills) or weekly (most injections). Label: the same molecule is often sold under two brands, one for diabetes and one for weight management, at different strengths (Wegovy vs Ozempic).
Not approved
Retatrutide, CagriSema, MariTide, survodutide and other pipeline drugs are investigational. "Research" vials of these or of approved molecules are not FDA-approved products, and their contents are unverified. See retatrutide vs tirzepatide for the trial picture.
Side effects across the class
Gastrointestinal effects dominate for every brand. Shared label warnings include pancreatitis, gallbladder disease, dehydration-related kidney injury and thyroid C-cell tumours in rodents. See GLP-1 side effects.
What users report here
Anonymous accounts are collected on the semaglutide, tirzepatide and liraglutide hubs. #686 (semaglutide) describes less joint inflammation early on; #43 describes hair thinning. Personal stories, not evidence of effect. In Canada the brand list differs: see GLP-1 medications in Canada.
Related topics
community guides:
More confessions from the archive
Community Q&A
- Which GLP-1 medication causes the most weight loss?
- In head-to-head trials tirzepatide (Zepbound) produced more weight loss than semaglutide (Wegovy). Individual results and suitability vary; a prescriber decides.
- Are there generic GLP-1 medications in the US?
- Liraglutide (Victoza, Saxenda) has generics. Semaglutide and tirzepatide do not as of October 2026.
- Which GLP-1s are pills?
- Rybelsus and the Wegovy pill (oral semaglutide) and Foundayo (orforglipron).
- What GLP-1 medications are approved for weight loss?
- In the US: Wegovy (injection and pill), Zepbound, Saxenda and Foundayo carry weight-management labels.
- Is tirzepatide a GLP-1?
- It is a dual GLP-1 and GIP receptor agonist, usually grouped with GLP-1 drugs.
- What is a GLP-1 agonist?
- A drug that activates the GLP-1 receptor, mimicking a natural gut hormone involved in insulin release and appetite.
- Does this page give dosing advice?
- Peptide Confessions does not publish dosing, timing, injection or sourcing guidance.
Sources
- Zepbound (tirzepatide) prescribing information — DailyMed (NLM)
- Mounjaro (tirzepatide) prescribing information — DailyMed (NLM)
- Wegovy (semaglutide) prescribing information — DailyMed (NLM)
- Ozempic (semaglutide) prescribing information — DailyMed (NLM)
- Saxenda (liraglutide) prescribing information — DailyMed (NLM)
Anonymous first-hand reports plus sourced context — educational only, not medical advice. Editorial policy & corrections.