Tirzepatide: What 129 Users Report
Dual GIP and GLP-1 receptor agonist sold as Mounjaro and Zepbound. Approved for type 2 diabetes and obesity; weekly injectable.
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Anonymous user report. Not medical advice. Peptides discussed are not FDA-approved for the uses described. Editorial process →
What is tirzepatide?
Tirzepatide is a once-weekly GIP and GLP-1 receptor agonist, sold by prescription as Mounjaro and Zepbound. People on this site also write it as tirz. Many of the confessions describe compounded or grey-market supply instead of a prescription. This site does not sell or recommend any source.
The side-effect numbers have their own page: tirzepatide side effects data report. This page is the wider picture: results, stalls, switches, and what happens after stopping.
What the trials show
In SURMOUNT-1, adults with obesity lost an average of 20.9% of body weight over 72 weeks at the highest dose, vs 3.1% with placebo. In SURMOUNT-5, the head-to-head trial, average loss was 20.2% with tirzepatide vs 13.7% with semaglutide. Most common side effects were gastrointestinal, mostly during dose increases; the Zepbound label also lists hair loss and fatigue above placebo. Last reviewed: October 2026.
Tirzepatide reports by the numbers
There are currently 129 published confessions tagged tirzepatide. Each was read and sorted by what the writer says happened. A report can sit in more than one row, and many are opinions, comparisons, or questions with no outcome. These are counts of stories, not rates.
| What the confession says | Count (mid-October read) | Examples |
|---|---|---|
| Also tagged retatrutide | 48 | #42, #392, #628 |
| Also tagged semaglutide | 10 | #43, #384, #668 |
| Gives a weight-loss figure | 21 | #384, #472, #816 |
| Weight loss stalled | 4 | #392, #517, #619 |
| Moved from tirzepatide to retatrutide | 7 | #42, #392, #394 |
| Weight or hunger came back after stopping | 3 | #200, #495, #614 |
| Sulfur burps or stomach trouble | 3 | #190, #276, #450 |
| Heart racing | 2 | #264, #290 |
| Less urge to drink or other compulsions | 3 | #104, #131, #820 |
| Another condition improved (migraine, reflux, A1C, allergies, anxiety) | 5 | #105, #113, #293, #308, #665 |
Tirzepatide results users describe
Weight is the main subject. #384 says semaglutide made overeating miserable while tirzepatide left "0 interest" in food, and credits it with most of a 57-pound loss. #472 reports 50 pounds. #816 is down 70. Others stall: #517 is stuck after 37 pounds, and #392 lost roughly ten pounds in eight months.
Some of the most specific reports are not about weight. #820 says the urge to drink went away. #293 describes an A1C falling from 8.3. #308 says fifteen years of reflux eased after a hard first week. These are the writers' accounts, not results to expect.
Stopping tirzepatide: what people report
#200 quit after a year and regained 30 of 50 pounds in four months. #614 stopped at goal weight and says the hunger came straight back. #590 is planning to come off at a healthy BMI. Anyone thinking about stopping a prescribed medicine should talk to the prescriber.
Tirzepatide vs retatrutide and semaglutide
Over half of these reports also name retatrutide, usually as the next step after a stall. Comparisons are collected at retatrutide vs tirzepatide and semaglutide vs tirzepatide. Neither page picks a winner. The ranked list of what fat-loss confessions mention is best peptides for fat loss.
This is not a dosing recommendation.
more topics on these reports:
Anonymous tirzepatide reports
Im a peptide fanatic. Two years deep in peptides. Honest notes, just what each actually does in my body. CJC-1295 with Ipamorelin is my sleep fix. Used to wake five times a night, now I'm out cold till morning. GHK-Cu I'll never drop. Tore my forearm open on a bike chain last summer and it closed clean enough to surprise the urgent care guy. SS-31 is the weird one. Closest thing to the lights coming on, and my recovery between hard sessions got noticeably shorter. Semax flips my focus to overdrive. Great for deadlines, useless past early afternoon or I can't sleep. Tirzepatide slowed my gut so much I had to move my night supplements earlier, they just sit there otherwise. BPC-157 is the quiet one for joints and gut. I only notice it when I run out. Thing nobody warns you about with almost all of them: water weight. I'll wake up 5 pounds up and it's pure sodium, not fat. Took me way too long to stop letting the scale wreck my morning.
#110Community Q&A
- What do tirzepatide users report?
- In a mid-October read of the published tirzepatide confessions, 21 give a weight-loss figure, 4 describe a stall, and 3 describe weight or hunger returning after stopping. 5 describe another condition improving, such as migraines or reflux. These are self-reports, not trial results.
- What tirzepatide side effects come up?
- Sulfur burps and stomach trouble (#190, #276, #450) and a racing heart (#290, and #264 on a three-drug stack) appear here. The full phrase-matched counts are on the tirzepatide side effects data report.
- Do people regain weight after stopping tirzepatide?
- Three reports describe it: 30 of 50 pounds back in four months (#200), hunger returning immediately (#614), and regaining weight after tapering off two GLP-1s (#495). This is not a rate.
- Why do people switch from tirzepatide to retatrutide?
- Usually a stall. 7 reports describe moving from tirzepatide to retatrutide, and several others say they prefer tirzepatide's side-effect profile or price. See the retatrutide vs tirzepatide comparison.
- Is this page a tirzepatide dosing guide?
- No. Doses mentioned in confessions are summarised on the data report with their method. This is not a dosing recommendation, and the site does not name or recommend suppliers.
- How long does it take to lose weight on tirzepatide?
- Individual results cannot be predicted. In SURMOUNT-1, average weight loss built gradually over 72 weeks, reaching about 20% at the highest dose.
- What are the main adverse events with tirzepatide?
- Nausea, diarrhea, vomiting, constipation and reduced appetite are most common. The label also warns about pancreatitis, gallbladder disease, kidney injury from dehydration and, in a boxed warning, thyroid C-cell tumours seen in rodents.
Sources
Anonymous first-hand reports plus sourced context — educational only, not medical advice. Editorial policy & corrections.