Peptides for Weight Loss

Anonymous accounts from people using peptides for fat loss — semaglutide, tirzepatide, retatrutide, AOD-9604. What worked, what didn't, and what nobody mentions in the forums.

65 anonymous reports

Reta makes me feel like im a monk, complete zen.

#148
Retatrutide

I have been struggling with seborrheic dermatitis in my scalp for more than 15 years, crusts, dandruff, greasy and dry hair, tried everything: zinc, ketoconazole, salicylic acid, charcoal, tea tree; you name it. Since December of last year I started "researching" with peptides: KLOW, Reta, KPV, TA-1... and next thing you know my dermatitis is gone.

#147
Thymosin Alpha-1RetatrutideKPV

31M - Retatrutide/MOTS-C/GHK-CU That’s it that’s the stack. Don’t over complicate it

#143
MOTS-cRetatrutideGHK-Cu

I stopped vaping after years, thanks to reta. I’ve always struggled with food and food noise until reta came along. My weekend interval training improved because of MOTS-C, and GHK-Cu has my skin looking like I’m 20 again. And I’m not even 30 yet.

#132
MOTS-cRetatrutideGHK-Cu

I started with Reta and now I have 7 different peptides in my weekly stack as well as TRT

#130
Retatrutide

When I upped by retatrutide dose to 4mg, I started having severe sleeping issues, profuse sweating, extreme tiredness and lethargy, brain fog. No appetite suppression or weight loss but paradoxical increase in appetite. Has this happened to anyone?

#129
Retatrutide

Tirzepatide cured my constant horrible migraines. Had them 1-2 times a week since I was 22. I'm 57 and life is now amazing.

#105
Tirzepatide

I threw away my first vial of Reta cause I thought it was fake and not dissolving reality was I was injecting air into the vial…

#098
Retatrutide

Been on 1.5mg/wk of Reta for four weeks now. My sleep has gone from consistently sleeping 7-8 hours straight to waking up at 2 AM and not being able to fall back asleep until 4 or 5 AM. Feeling train wrecked each morning isn’t worth it.

#096
Retatrutide

the reta cardiovascular thing is real but it's dose-dependent. my RHR was fine at 2-4mg and only climbed once I pushed past 6. everyone screaming about heart rate is maxing the dose because they think more = faster. you don't need 12mg. most people get full results at 4-6 and skip the side effects.

#083
Retatrutide

Day 19. Reta, 4mg. 3:47am. Heart rate 178. BP 180/130. Sitting upright in bed because lying down felt like drowning. Did not wake my wife. Could not explain what I had been injecting. Drove myself. Told the ER it was pharmacy tirz. They ran $11,400 of workup. Found nothing. Discharged at 7am with a referral to cardiology. Threw out $2,800 of reta that afternoon. Eight months later: the palpitations come back maybe twice a week. Cardiology calls it anxiety. It is not anxiety. My wife still thinks it was a panic attack. I will let her keep thinking that.

#069
TirzepatideRetatrutide

things i learned the hard way on retatrutide: the nausea peaks at week 3 not week 1 alcohol becomes literally toxic, one beer = food poisoning sulfur burps mean you're titrating too fast the "ozempic face" thing is real and arrives at month 4 nobody tells you any of this until you post about it

#055
SemaglutideRetatrutide

Donated blood while on reta ghk bpc mots tb500

#052
TB-500BPC-157RetatrutideGHK-Cu

Skipped the gym for a year. Took reta. Lost 40 pounds, looked better than my friends who train six days a week. Genetics is a meme and pharmacology is the answer.

#047
Retatrutide

Semaglutide cured my type 2 diabetes, full remission

#041
Semaglutide

Recovered from diabetes in 6 months using reta. Selank also significantly improved my anxiety.

#038
SelankRetatrutide

I lost 35lbs with Reta in 3 months without stepping into the gym even once but I told everyone who asked that I lost it by going to the gym and eating better

#034
Retatrutide

a 10mg vial of retatrutide from a pharmacy: $1,400/month.the same molecule, same purity, from a research vendor: $89.the gap between those two numbers is the entire weight loss industry.

#028
Retatrutide

I’m addicted to Retatrutide

#022
Retatrutide

Semax 1 mg SubQ in the morning gives a nice mental boost, clarity and crisp focus.

#012
SemaglutideSemax
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community guides:

Peptides for Weight LossBest Peptide StacksInjecting Peptides

related topics:

Semaglutide vs TirzepatideBefore and AfterBest Peptide StacksPeptides for Women

Community Q&A

What is the best peptide for fat loss?
Based on volume of community accounts, semaglutide and tirzepatide are by far the most-reported peptides for fat loss — appearing at roughly 10× the frequency of any other compound. Among non-GLP-1 options, CJC-1295 with ipamorelin is the most commonly cited stack, described as improving body composition over 3–6 months rather than producing rapid loss. AOD-9604 and HGH Fragment 176-191 appear in fat-loss accounts but with less consistent reported outcomes than the GLP-1s.
How long do peptides take to work for weight loss?
Community timelines split sharply by compound. GLP-1 accounts (semaglutide, tirzepatide) describe meaningful weight changes within 4–8 weeks — often 5–15 lbs in the first month at therapeutic doses. GH secretagogue accounts (CJC-1295, ipamorelin, sermorelin) describe a slower curve: improved body composition over 3–6 months, with earliest noticeable changes at 6–8 weeks. Accounts expecting quick fat loss from GH peptides consistently report disappointment.
What peptide makes you lose weight the fastest?
Community accounts give tirzepatide the edge over semaglutide for speed and total weight loss at equivalent doses — a finding consistent across multiple comparative accounts. Retatrutide appears in early community reports as potentially even more aggressive for weight reduction, though the account volume is still small. Among non-GLP-1 peptides, no compound comes close to GLP-1 speed; the fastest non-GLP-1 weight-loss accounts still describe weeks-to-months timelines.
Peptides for Weight Loss: Anonymous Reports — Page 2 — Peptide Confessions