Peptides and Mental Health: What Users Report

Switching from Reta to Tirz was the best decision ever. 35f, I was on Reta for 3 months. Most of it was 4 mg but tried titrating up to 6mg twice and both times was beyond awful. I had bad smell from my mouth , sleep disruption and crippling anxiety. it was purely the Reta. I did all the things (very strictly) - ate enough calories, drank 2-2.5 litres of water, electrolytes, elemental magnesium, all of it to manage the air hunger and anxiety. I made sure to follow all the tips.. Then, I switched to Tirz. I did 6 wks on 2.5mg and then titrated to 5mg. I was honestly quite terrified / scared to titrate but it in reality it was truly so gentle on my system! Appetite suppression is great with no other symptoms. I don’t have to manage anything excessively. I can drink without it destroying me. everything is 10x better and much more pleasant!!! I am still losing weight. It is a bit slower (approx0.5-1lbs a week) but that’s also because I’m just a couple pounds away from my goal weight.

Thoses last years I tried on and off sema, tirz and I’ve been on Reta the last month; only low dose like 1-2mg. Since it’s a low dose I only feel the glucagon effect on day 2-3 after injectio. It gets my heart racing, mess with my sleep and kick anxiety up, contributing to fatigue and poor mental health. Do you think I should go back on tirz or should I try going higher on Reta? It can sounds stupid but if I go higher the glucagon effect would be always here and maybe my body and mind would adapt to it instead of always be surprised by it. Or if it goes wrong : bad effect all the the time, and stronger effect. Would appreciate people who would have experienced higher dose. Is there a moment where glucagon does its magic and not only get non enjoyable effect?

My husband has been taking Reta for six months. To get straight to the point: his erectile dysfunction has gotten even worse. He’s lost his appetite and his sex drive. Aside from the physical symptoms, his mood has also gotten much worse. So maybe I’m just imagining things, but I’m not a fan of Reta.

GOD BLESS ! Long COVID since January 2022. Out of breath on stairs, brain fog bad enough that I wrote my PIN on my hand. Thymosin alpha-1 twice a week for 12 weeks. Stairs are fine now. Fog maybe 60% better. My long COVID clinic discharged me in March because they had nothing else to try

I started Reta in February. I have lost 70 pounds in 9 months. While I look FANTASTIC (my goal was to lose 110 pounds and I'm still trying to reach that goal) I feel horrible. I don't feel the clear focus everyone else does. I am always frightened. My anxiety is taking over my life and I fear it is causing my relationship with my boyfriend to fracture. I am always paranoid that he is going to leave me or is cheating on me. I am depressed. I am taking 12.5mg once a week. I am going to titrate down to see if that works. Overall thrilled with how my body looks but my mind is an absolute mess. I used to be so centered and in control.

11 months later on tirz and a new life, My ex dumped me for "letting myself go" after I lost my mom and fell into a depression, got quite fat.He liked 3 of my gym pics in one night at 1:47am. Will I respond? Of course fucking not.

- This was a message I wrote 6 months ago: I am done , it's been 8 years , I got a fever at 15 in 2018 and never recovered. I don't know how to live anymore , no doctor here will diagnose me , nobody believes me , I have to go to college and lose my mind every 2nd day. I am depressed, obese and hate my life , it is so severe that I’ve considered ending my life… I don't know which test will help , I’ve had endless blood tests , MRI and CT scans , nothing came up except minor vitamin D and B12 deficiencies , now treated , so now what ? I am just going to end it all - Present day on Retatrutide (6mg weekly) : I am 80 pounds down, my pains are gone, my depression is a thing of the past, the clouds are gone and I finally see the sunshine. I am seeing a girl I really like, first girlfriend in a decade. I wrote this confession hoping it reaches someone going through a similar experience, please don’t hurt yourself

I avoided SSRIs because the side effects scared me. Always wanted to do things naturally.Now I inject Selank... honestly? I feel better!! Social anxiety had reached the point where even being around longtime friends felt uncomfortable. On Selank, conversations became easier and I stopped analysing myself so much.

I had made a previous confession where I said I was heavily depressed and almost suicidal. Thank you to almost everyone who replied lol. To clarify, I'm a woman so being told to check my testosterone and being called bro was kinda funny. After getting some rest and time to think of it, I think I'm mostly depressed because I've come to the bleak realization that I hate my job and most of my life. With reta working on dopamine levels, almost all sources of enjoyment that I used to have now make me feel indifferent. So reta is actually working as a catalyst for me to reevaluate my whole life. I'm starting to understand what I want and need from life after years of navigating through it aimlessly. I'm still quitting reta for tirz because I can't take the elevated RHR but I still think this experience eventually resulted in something positive ✨ Currently taking a two-week break from GLP-1s to start over with tirz.

I accidentally took 12mg instead of my regular 6mg dose of Reta, and I went insane for a couple weeks. Anxiety through the roof, intrusive thoughts, SI, and was genuinely scared for my family. It's been a rough couple weeks and I feel okay now. I will never touch any peptides again in my life.

Here’s how trying to finish my weight loss went: Ozempic: lost 50 pounds. Tirzepatide: lost another 67. Fourteen pounds left to goal. Switched to retatrutide. Three months later, I’d gained ten pounds and the anxiety was interfering with everyday life. I eventually stopped reta and moved back to tirzepatide with cagrilintide. The following month I lost six pounds and felt much better. I’d already lost 117 p

One thing I did not expect to lose on Retatrutide is my will to live. This thing has made me so depressed and short-tempered, I started having suicidal ideation and shouting at people at work. My tolerance for bs is veryyyyy low now. And no, it's not due to the calorie deficit either, because I'm not losing weight anymore and the appetite suppression is now long gone. I am eating at maintenance. Retatrutide will make you depressed, please know this before you consider taking it. Please someone tell me tirzepatide is different. I can't take it anymore but I still need to lose the weight.

My anxiety got bad enough that I needed time off work. Prozac helped, but like was still harsh to me and tough. After adding Selank, I find myself sitting in the lunchroom chatting the way I used to before the panic attacks.

Tried Semax and Selank for a week. Felt good for the first couple times then I developed massive anxiety attacks when trying to sleep and general anxiety during the rest of the days. This is coming from someone who used to have a Xanax addiction. It’s not as bad as coming off of Xanax but it 1000% is not worth even trying. Low reward high risk. The good news is I feel way better after two days of stopping. Live and learn with these RESEARCH chemicals.