#655

One thing I did not expect to lose on Retatrutide is my will to live.

One thing I did not expect to lose on Retatrutide is my will to live. This thing has made me so depressed and short-tempered, I started having suicidal ideation and shouting at people at work. My tolerance for bs is veryyyyy low now. And no, it's not due to the calorie deficit either, because I'm not losing weight anymore and the appetite suppression is now long gone. I am eating at maintenance. Retatrutide will make you depressed, please know this before you consider taking it. Please someone tell me tirzepatide is different. I can't take it anymore but I still need to lose the weight.

Anonymous user report. Not medical advice. Peptides discussed are not FDA-approved for the uses described. Editorial process →

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Published September 17, 2026