Data report
Most reported retatrutide side effects: what 342 anonymous confessions say
Counts from published confessions tagged Retatrutide. What users report is read off the published text. The archive has no side-effect column, so each figure is a phrase match. This is not a clinical rate, and it is not medical advice.
Headline stats
Of 342 published anonymous confessions tagged retatrutide, 22 (6.4%) mention heart rate or palpitations. 74 name a retatrutide milligram figure, and 41 state a pound loss with lost, down, or dropped. Data through 19 October 2026. These are self-reports, not clinical incidence, and the doses are not a recommendation.
- Published confessions
- 342
- Most mentioned side-effect phrase
- Heart rate or palpitations · 22 (6.4%)
- Confessions with any side-effect phrase
- 57
- Confessions naming a figure
- 74
- Most named figure
- 2 mg · 19 confessions
- Confessions naming a week
- 54
- Confessions naming a month
- 44
- Confessions stating a pound loss
- 41 · median 30 lb
342 published confessions, 20 May 2026 through 19 October 2026 (UTC). 57 mention at least one side-effect phrase in the lexicon below.
Side effects mentioned
Share of published retatrutide confessions whose text matches the phrase. One confession can match more than one row. A denial next to the phrase is not counted. What users report is a phrase, not a diagnosis.
| Phrase | Confessions | % | Share of corpus |
|---|---|---|---|
| Heart rate or palpitations | 22 | 6.4% | |
| Anxiety or panic | 9 | 2.6% | |
| Low mood or anhedonia | 8 | 2.3% | |
| Nausea | 7 | 2% | |
| Fatigue or exhaustion | 6 | 1.8% | |
| Libido | 6 | 1.8% | |
| Burping | 5 | 1.5% | |
| Constipation | 4 | 1.2% | |
| Insomnia or poor sleep | 4 | 1.2% | |
| Dizziness | 3 | 0.9% | |
| Vomiting | 3 | 0.9% | |
| Cramps | 2 | 0.6% | |
| Injection-site reaction | 2 | 0.6% | |
| Sensitive skin | 2 | 0.6% | |
| Diarrhea | 1 | 0.3% | |
| Hair shedding | 1 | 0.3% | |
| Muscle loss | 1 | 0.3% | |
| Reflux or heartburn | 1 | 0.3% | |
| Headache | 0 | 0% |
Also written, not scored as a side effect
Appetite and hunger are the change these confessions usually set out to describe. “No side effects” is a phrase about the absence of effects.
| Phrase | Confessions | % | Share of corpus |
|---|---|---|---|
| Appetite, hunger, or food noise | 33 | 9.6% | |
| "No", "zero", or "minimal" side effects | 6 | 1.8% |
Reported doses
A milligram figure counts when it is written next to reta or retatrutide. Figures next to another compound, a price, or a vial size are left out, as are amounts above 20 mg. Each distinct figure counts once per confession. Figures that appear in only one confession are omitted from the table.
This is not a dosing recommendation.
74 of 342 confessions (21.6%) name at least one such figure. 6 other figures appear in a single confession and are not listed.
| Figure | Confessions | % of corpus | % of confessions with a figure |
|---|---|---|---|
| 2 mg | 19 | 5.6% | 25.7% |
| 4 mg | 16 | 4.7% | 21.6% |
| 0.5 mg | 11 | 3.2% | 14.9% |
| 1 mg | 10 | 2.9% | 13.5% |
| 6 mg | 8 | 2.3% | 10.8% |
| 8 mg | 6 | 1.8% | 8.1% |
| 1.5 mg | 5 | 1.5% | 6.8% |
| 0.25 mg | 3 | 0.9% | 4.1% |
| 3 mg | 3 | 0.9% | 4.1% |
| 5 mg | 3 | 0.9% | 4.1% |
| 12 mg | 3 | 0.9% | 4.1% |
| 10 mg | 2 | 0.6% | 2.7% |
Timelines
Week numbers and month numbers are counted separately. A month is not turned into four weeks. A confession that names two different weeks can appear in two week rows.
Weeks (54 confessions name a week)
| Range | Confessions | % | Share of corpus |
|---|---|---|---|
| 1–4 weeks | 19 | 5.6% | |
| 5–8 weeks | 21 | 6.1% | |
| 9–12 weeks | 6 | 1.8% | |
| 13–26 weeks | 7 | 2% | |
| 27 weeks or more | 2 | 0.6% |
Months (44 confessions name a month)
| Range | Confessions | % | Share of corpus |
|---|---|---|---|
| 1–2 months | 11 | 3.2% | |
| 3–5 months | 19 | 5.6% | |
| 6–11 months | 12 | 3.5% | |
| 12 months or more | 3 | 0.9% |
Outcomes written in the text
A weight figure counts only when it follows lost, down, or dropped. Kilograms stay in kilograms. A figure next to tirzepatide, semaglutide, Mounjaro, Ozempic, or Wegovy is left out. Start weight and end weight with no unit are left out. What users report is not a result to expect.
Pound losses: 41 confessions. Median 30 lb, range 1.5–90 lb. Kilogram losses: 3 confessions. Median 9 kg, range 1–25 kg.
| Range | Confessions | % | Share of corpus |
|---|---|---|---|
| Under 10 lb | 4 | 1.2% | |
| 10–19 lb | 7 | 2% | |
| 20–39 lb | 14 | 4.1% | |
| 40–59 lb | 8 | 2.3% | |
| 60 lb or more | 8 | 2.3% |
| Phrase | Confessions | % | Share of corpus |
|---|---|---|---|
| Says they stopped, quit, or came off retatrutide | 4 | 1.2% |
Related confessions
The newest published confession for each of the most mentioned side effects. The full archive is on the retatrutide page.
Heart rate or palpitations
Was on Tirz. Shifted to Reta. Tanked my HRV and RHR shot off more than 18-20pts. Stalled. However a Dexa scan revealed massive fat loss, especially visceral fat. However given a…#773 · 7 October 2026
Anxiety or panic
I started Reta in February. I have lost 70 pounds in 9 months. While I look FANTASTIC (my goal was to lose 110 pounds and I'm still trying to reach that goal) I feel horrible. I…#831 · 15 October 2026
Low mood or anhedonia
- This was a message I wrote 6 months ago: I am done , it's been 8 years , I got a fever at 15 in 2018 and never recovered. I don't know how to live anymore , no doctor here wil…#802 · 13 October 2026
Nausea
I've been taking Reta since March. Started on 0.5mg, currently taking 7mg weekly. Nausea has been a major side effect for me. I've somehow managed to condition myself to start r…#578 · 6 September 2026
Fatigue or exhaustion
This is a crazy one for all the ladies out there. I lose about a week every month to PMS and my period. Cramps, exhaustion, getting very little done. This month, after starting…#644 · 16 September 2026
Retatrutide in Canada
Health Canada has not authorized retatrutide for any use; it remains an investigational drug. Its April 2026 advisory names retatrutide among unauthorized injectable peptides it has seized, and states that “For Research Use Only” labelling does not make a product legal or exempt (Health Canada).
More context: are peptides legal in Canada? and the Peptides in Canada hub. We do not publish sourcing or dosing advice. Not legal or medical advice.
How to cite
The sentence in the summary is the citable line. The block below is HTML; it uses the same numbers as this page.
<blockquote cite="https://www.peptideconfessions.com/reports/retatrutide-side-effects"> <p>Of 342 published anonymous confessions tagged retatrutide, 22 (6.4%) mention heart rate or palpitations. 74 name a retatrutide milligram figure, and 41 state a pound loss with lost, down, or dropped. Data through 19 October 2026. These are self-reports, not clinical incidence, and the doses are not a recommendation.</p> <footer>Source: <a href="https://www.peptideconfessions.com/reports/retatrutide-side-effects">Peptide Confessions, retatrutide side-effect report</a>. Anonymous published confessions through 19 October 2026. Not medical advice. This is not a dosing recommendation.</footer> </blockquote>
Questions
- How many confessions are in this count?
- 342 published confessions are tagged retatrutide. The site has no accounts, so this is a count of submissions, not a verified count of distinct people. Published dates run from 20 May 2026 through 19 October 2026.
- What counts as mentioning a side effect?
- A confession counts when its text matches a fixed phrase list (for example nausea, constipation, heart rate, palpitations). A denial in the preceding words ("no nausea") does not count. The most mentioned side effect in the lexicon is heart rate or palpitations: 22 of 342 confessions (6.4%). Silence is not recorded: people who never name an effect are in the denominator only.
- Are these doses a recommendation?
- No. 74 of 342 confessions write a milligram figure next to retatrutide. Figures are kept when they sit near the words reta or retatrutide, and dropped when they sit near another compound, a price, or a vial size. One distinct figure counts once per confession. The milligram figure named in the most confessions is 2 mg (19 confessions). Nothing here is a dose to copy.
- Does this show that retatrutide causes these effects?
- No. These are anonymous stories that an editor chose to publish. They are not a survey, not a trial, and not a rate of harm. A percentage is the share of published confessions that used a phrase.
- Why are weeks and months separate?
- 54 confessions write an explicit week number, and 44 write an explicit month number. Months are not converted into weeks. A confession can land in more than one week bucket when it names more than one week.
- How is weight loss counted?
- 41 confessions contain a pound figure written with lost, down, or dropped. 3 do the same in kilograms. Kilograms are not converted to pounds. A figure whose nearby subject is tirzepatide, semaglutide, or a brand name for those is left out. Start-and-end weights with no unit word are left out. The median is the middle value of the figures that remain.
- Which side effects are mentioned most often?
- The three most mentioned side-effect phrases are heart rate or palpitations (22 of 342, 6.4%), anxiety or panic (9 of 342, 2.6%), low mood or anhedonia (8 of 342, 2.3%). These are phrase mentions in anonymous stories, not clinical rates.
- What share of retatrutide confessions mention any side effect?
- 57 of 342 confessions (16.7%) match at least one side-effect phrase. The rest either describe no effect or do not name one in the lexicon.
- How many confessions give a timeline?
- 94 of 342 confessions (27.5%) write an explicit week or month number, which is what the timeline tables are built from.
- Is retatrutide approved in Canada?
- No. Health Canada has not authorized retatrutide for any use; it is an investigational drug and appears in Health Canada advisories listing seized unauthorized injectable peptides. 'Research use only' labelling does not make a product legal to sell. See our Canada pages for sources. This is not legal or medical advice.
Methodology
Cohort: confessions with status published and a Retatrutide tag. Data through 19 October 2026. The page is cached and regenerated about once an hour from that query.
There is no structured field for side effect, use, dose, week, or outcome. Matches are case-insensitive phrases. A phrase that nobody used stays in the table at zero. “Tired”, “sleep”, “heart”, and “skin” alone are not scored; those words show up in stories that are not about a side effect.
Figures on this page are phrase matches over anonymous published stories, not clinical incidence.
This is not a dosing recommendation. Doses are not a protocol. Weight figures, where this page shows them, are not a result you should expect. Nothing on this page is a finding from a trial.
Editorial rules for what gets published are on the methodology page. Vendor names are not repeated here.