Data report
MOTS-c side effects: what users report in 35 anonymous confessions
Counts from published confessions tagged MOTS-c. What users report about MOTS-c side effects is read off the published text. The archive has no side-effect column, so each figure is a phrase match. This is not a clinical rate, and it is not medical advice.
Headline stats
What users report in 35 published anonymous confessions tagged MOTS-c: 1 (2.9%) mention injection-site reaction. 6 name a MOTS-c milligram figure, and 3 state a pound loss with lost, down, or dropped. Data through 15 October 2026. Figures on this page are phrase matches over anonymous published stories, not clinical incidence. This is not a dosing recommendation.
- Published confessions
- 35
- Most mentioned side-effect phrase
- Injection-site reaction · 1 (2.9%)
- Confessions with any side-effect phrase
- 1
- Confessions naming a figure
- 6
- Most named figure
- 1 mg · 3 confessions
- Confessions naming a week
- 6
- Confessions naming a month
- 2
- Confessions stating a pound loss
- 3 · median 57.5 lb
35 published confessions, 29 May 2026 through 15 October 2026 (UTC). 1 mention at least one side-effect phrase in the lexicon below.
Side effects mentioned
Share of published MOTS-c confessions whose text matches the phrase. One confession can match more than one row. A denial next to the phrase is not counted. What users report is a phrase, not a diagnosis.
| Phrase | Confessions | % | Share of corpus |
|---|---|---|---|
| Injection-site reaction | 1 | 2.9% | |
| Anxiety or panic | 0 | 0% | |
| Burping | 0 | 0% | |
| Constipation | 0 | 0% | |
| Cramps | 0 | 0% | |
| Diarrhea | 0 | 0% | |
| Dizziness | 0 | 0% | |
| Fatigue or exhaustion | 0 | 0% | |
| Hair shedding | 0 | 0% | |
| Headache | 0 | 0% | |
| Heart rate or palpitations | 0 | 0% | |
| Insomnia or poor sleep | 0 | 0% | |
| Libido | 0 | 0% | |
| Low mood or anhedonia | 0 | 0% | |
| Muscle loss | 0 | 0% | |
| Nausea | 0 | 0% | |
| Reflux or heartburn | 0 | 0% | |
| Sensitive skin | 0 | 0% | |
| Vomiting | 0 | 0% |
Also written, not scored as a side effect
Appetite and hunger are the change these confessions usually set out to describe. “No side effects” is a phrase about the absence of effects.
| Phrase | Confessions | % | Share of corpus |
|---|---|---|---|
| Appetite, hunger, or food noise | 2 | 5.7% | |
| "No", "zero", or "minimal" side effects | 1 | 2.9% |
Reported doses
A milligram figure counts when it is written next to MOTS-c or mots. Figures next to another compound, a price, or a vial size are left out, as are amounts above 20 mg. Each distinct figure counts once per confession. Figures that appear in only one confession are omitted from the table.
This is not a dosing recommendation.
6 of 35 confessions (17.1%) name at least one such figure. 5 other figures appear in a single confession and are not listed.
| Figure | Confessions | % of corpus | % of confessions with a figure |
|---|---|---|---|
| 1 mg | 3 | 8.6% | 50% |
| 3 mg | 2 | 5.7% | 33.3% |
Timelines
Week numbers and month numbers are counted separately. A month is not turned into four weeks. A confession that names two different weeks can appear in two week rows.
Weeks (6 confessions name a week)
| Range | Confessions | % | Share of corpus |
|---|---|---|---|
| 1–4 weeks | 2 | 5.7% | |
| 5–8 weeks | 3 | 8.6% | |
| 9–12 weeks | 0 | 0% | |
| 13–26 weeks | 1 | 2.9% | |
| 27 weeks or more | 0 | 0% |
Months (2 confessions name a month)
| Range | Confessions | % | Share of corpus |
|---|---|---|---|
| 1–2 months | 0 | 0% | |
| 3–5 months | 0 | 0% | |
| 6–11 months | 1 | 2.9% | |
| 12 months or more | 1 | 2.9% |
Outcomes written in the text
A weight figure counts only when it follows lost, down, or dropped. Kilograms stay in kilograms. A figure next to tirzepatide, semaglutide, retatrutide, or a brand name for those is left out. Start weight and end weight with no unit are left out. What users report is not a result to expect.
Pound losses: 3 confessions. Median 57.5 lb, range 23–60 lb. Kilogram losses: 0 confessions. No kilogram figure matched.
| Range | Confessions | % | Share of corpus |
|---|---|---|---|
| Under 10 lb | 0 | 0% | |
| 10–19 lb | 0 | 0% | |
| 20–39 lb | 1 | 2.9% | |
| 40–59 lb | 1 | 2.9% | |
| 60 lb or more | 1 | 2.9% |
| Phrase | Confessions | % | Share of corpus |
|---|---|---|---|
| Says they stopped, quit, or came off MOTS-c | 0 | 0% |
Related confessions
The newest published confession for each of the most mentioned side effects. The full archive is on the MOTS-c page.
Injection-site reaction
Topical GHK-Cu seems like a waste to me. Your skin is a barrier, no way a big ass positively charged peptide like that is getting through in significant amounts. A needle bypass…#697 · 24 September 2026
How to cite
The sentence in the summary is the citable line. The block below is HTML; it uses the same numbers as this page.
<blockquote cite="https://www.peptideconfessions.com/reports/mots-c-side-effects"> <p>What users report in 35 published anonymous confessions tagged MOTS-c: 1 (2.9%) mention injection-site reaction. 6 name a MOTS-c milligram figure, and 3 state a pound loss with lost, down, or dropped. Data through 15 October 2026. Figures on this page are phrase matches over anonymous published stories, not clinical incidence. This is not a dosing recommendation.</p> <footer>Source: <a href="https://www.peptideconfessions.com/reports/mots-c-side-effects">Peptide Confessions, MOTS-c side-effect report</a>. Anonymous published confessions through 15 October 2026. Not medical advice. This is not a dosing recommendation.</footer> </blockquote>
Questions
- What MOTS-c side effects do users report?
- A confession counts when its text matches the shared phrase list (for example nausea, constipation, heart rate, palpitations). A denial in the preceding words ("no nausea") does not count. The side-effect phrase users report most often is injection-site reaction: 1 of 35 confessions (2.9%). Silence is not recorded: people who never name an effect are in the denominator only.
- How many confessions are in this MOTS-c count?
- 35 published confessions are tagged MOTS-c. The site has no accounts, so this is a count of submissions, not a verified count of distinct people. Published dates run from 29 May 2026 through 15 October 2026.
- Are these MOTS-c doses a recommendation?
- This is not a dosing recommendation. 6 of 35 confessions write a figure next to MOTS-c or mots. Figures are kept when they sit near that name, and dropped when they sit near another compound, a price, or a vial size. One distinct figure counts once per confession. The figure named in the most confessions is 1 mg (3 confessions).
- Do these percentages show what MOTS-c causes?
- A percentage is the share of published confessions that used a phrase. Figures on this page are phrase matches over anonymous published stories, not clinical incidence.
- Why are weeks and months separate?
- 6 confessions write an explicit week number, and 2 write an explicit month number. Months are not converted into weeks. A confession can land in more than one bucket when it names more than one number.
- How is weight loss counted?
- 3 confessions contain a pound figure written with lost, down, or dropped. 0 do the same in kilograms. Kilograms are not converted to pounds. A figure whose nearby subject is tirzepatide, semaglutide, retatrutide, or a brand name for those is left out. Start-and-end weights with no unit word are left out. The median is the middle value of the figures that remain. What users report here is not a result to expect.
Methodology
Cohort: confessions with status published and a MOTS-c tag. Data through 15 October 2026. The page is cached and regenerated about once an hour from that query.
There is no structured field for side effect, use, dose, week, or outcome. Matches are case-insensitive phrases. A phrase that nobody used stays in the table at zero. “Tired”, “sleep”, “heart”, and “skin” alone are not scored; those words show up in stories that are not about a side effect.
Figures on this page are phrase matches over anonymous published stories, not clinical incidence.
This is not a dosing recommendation. Doses are not a protocol. Weight figures, where this page shows them, are not a result you should expect. Nothing on this page is a finding from a trial.
Editorial rules for what gets published are on the methodology page. Vendor names are not repeated here.