Retatrutide — Experiences & Side Effects

Triple agonist at GIP, GLP-1, and glucagon receptors. Phase 3 trials show weight loss exceeding current approved GLP-1 medications.

48 anonymous reports
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Also known as:

retaretatrutide peptidely3437943

often mentioned with:

TirzepatideGHK-CuMOTS-cBPC-157

browse topics:

Peptides for Weight Loss

community guides:

Peptides for Weight LossBest Peptide StacksInjecting Peptides

Reta MOTS-C Hydration Powder Magnesium Powder Fiber Powder Omega Pill Multi-Vitamin (B Complex) Make sure you’re not vitamin D deficient

#153

6 months on reta, down 60 lbs, about 25% of my bodyweight. I look better than I have in my adult life and people keep telling me how happy I must be. here's what nobody puts in the before/afters: it didn't just kill my appetite, it killed my drive. the same thing that quiets the food noise quiets everything. I used to attack my mornings. now I have to schedule motivation like it's a meeting. lost the weight, lost the fire that used to come free with being hungry. nobody warned me they were wired to the same switch.

#152
Success Stories

Unemployed and getting low on savings but so eager to buy more peps. Currently on KLOW,Reta, cjc/ipa. Just want more thinking about a payment plan and buying tons. Love em gotttta catch em all 😂

#151
CJC-1295 / Ipamorelin Stack

Reta makes me feel like im a monk, complete zen.

#148
Peptides for Weight Loss

I have been struggling with seborrheic dermatitis in my scalp for more than 15 years, crusts, dandruff, greasy and dry hair, tried everything: zinc, ketoconazole, salicylic acid, charcoal, tea tree; you name it. Since December of last year I started "researching" with peptides: KLOW, Reta, KPV, TA-1... and next thing you know my dermatitis is gone.

#147
Peptides for Weight LossPeptides for RecoveryPeptides for WomenBest Peptide StacksKPV PeptidePeptides for Hair

Reta at 2mg per week for 2 weeks, zero side effects, upping to 4mg this week.

#144
Peptides for Weight LossPeptide Side Effects

31M - Retatrutide/MOTS-C/GHK-CU That’s it that’s the stack. Don’t over complicate it

#143
StackingPeptides for Weight LossPeptides for LongevityPeptides for RecoveryPeptides for WomenBest Peptide StacksPeptides for Skin

im starting reta on flag day after my fam has a visit. after that going straight in and crushing til ive lost 40-50lbs. I haven’t been below 190lbs since before covid (5’8”) and w/ a move and big life changes ahead im ready to look amazing

#142
Success StoriesPeptides for Weight Loss
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Community Q&A

What is retatrutide?
Community accounts describe retatrutide as the next generation beyond tirzepatide — a triple agonist hitting GIP, GLP-1, and glucagon receptors simultaneously. The glucagon component is described as the key differentiator, adding metabolic rate elevation to the appetite suppression mechanisms of the dual agonists. Early community accounts come predominantly from early adopters who describe sourcing it through compounding channels before wider availability. Most frame it as producing faster and greater weight loss than tirzepatide at comparable dose stages.
How much weight can you lose on retatrutide?
Early community accounts describe weight loss in the range of 25–35% of starting body weight over 6–12 months, with some accounts exceeding this. The consistent framing in confessions: retatrutide outpaces tirzepatide, which already outpaces semaglutide. Side effect accounts describe a similar GI adjustment period to other GLP-1s, with nausea dominating early weeks. Account volume is still low compared to semaglutide and tirzepatide — early adopter reports rather than established community consensus.
Retatrutide vs tirzepatide — what's the difference?
Community accounts that compare both describe retatrutide as producing faster and greater weight loss, at the cost of a more pronounced adjustment period. The glucagon receptor component is described in accounts as increasing energy expenditure — the mechanism absent in tirzepatide. Accounts switching from tirzepatide to retatrutide describe continued weight loss after a tirzepatide plateau. Side effect profiles are described as broadly similar, with retatrutide's early nausea slightly more intense in comparison accounts.