Semaglutide: Weight Loss (Anonymous Report) #825

​I turned to GLP-1s to fix a metabolism wrecked by an ill-advised growth hormone protocol. Severe insulin resistance hit overnight, spiking my HOMA-IR and making me terrified of clean carbs. ​Semaglutide helped initially, then stalled. What no one told me is that prior GLP-1 exposure means Retatrutide requires much higher starting doses. I lost months of frustration and serious money on low titration doses feeling zero effect until finally hitting 6 mg. Still, seeing 95 kg frozen on the scale is mentally exhausting. ​I run CJC/Ipamorelin to protect muscle, but water retention masks progress. Balancing fasts, night pins, and metabolic healing feels isolating when people only talk about easy drops. If you're stuck on a plateau after prior GLP-1 use, don't lose hope—you're not alone.

People keep talking about “Ozempic divorces.” My husband has secret children. Plural. Reta has made me feel more confident about dating again, which does make leaving easier. But the marriage already had plenty of reasons to end.

Everyone on X glorifies Reta, I did Ozempic for 1 year, currently on month 3 of Reta.. not happy. Losing less weight, feel more nauseous etc.. im currently on 2mg twice per week

Bro I can’t run any of the GLPs. Sema, Tirz, and, Reta all give me full-body histamine dump. Flushing, itching, hives. Using these that actually move the scale are off the table. Here I am sitting here 60 lbs overweight watching people drop 30–50. It sucks. Silver lining. I've read that some come off these drugs with zero libido, someone said that they don’t even care to rawdog hookers anymore. Nice knowing I still have that option.

So here we go, most will call this fake. Started semaglutide in February. By April, didnt lose even 1 pound. Most would say I got scammed or that peptide wasn't the right one, I kept taking it, my feet and joints felt less inflamed within the first couple of weeks. The next month, my wedding ring started getting loose. Then my period came back. I have PCOS. The last one had been three or four years earlier, when I was following strict keto and actively trying to get pregnant. I still wanted the weight loss. Of course I did. But getting my period after years without one made it difficult to look at the unchanged scale and call those months a failure.

Here’s how trying to finish my weight loss went: Ozempic: lost 50 pounds. Tirzepatide: lost another 67. Fourteen pounds left to goal. Switched to retatrutide. Three months later, I’d gained ten pounds and the anxiety was interfering with everyday life. I eventually stopped reta and moved back to tirzepatide with cagrilintide. The following month I lost six pounds and felt much better. I’d already lost 117 p

I’d used semaglutide without this happening. On retatrutide, my distance vision started going blurry after I increased the amount. I went to an eye doctor. She compared my scans and said the retina and blood vessels looked fine.

Sema: Lost 80 pounds year 1 and everyone said I was glowing. Year two Im in hospital every few weeks for vomiting they say it will "settle." Gastroparesis. I stopped the drug months ago. I am still vomiting. I've lost my job, my savings, and 150 pounds I didn't want to lose. My lesson for this decade? Just go on a calorie deficit and don't be lazy, it's not worth it.