TB-500 (Thymosin Beta-4 Fragment): What 29 Users Report
Synthetic fragment of thymosin beta-4, a protein found in blood platelets and wound fluid. Studied for its role in tissue repair signaling.
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Anonymous user report. Not medical advice. Peptides discussed are not FDA-approved for the uses described. Editorial process →
What is TB-500?
TB-500 is a synthetic fragment related to thymosin beta-4, a protein found in platelets and wound fluid. It has been studied in lab and animal work on tissue repair. It is not approved for human use.
The line above is the compound. Everything after it is what people wrote in the confessions tagged TB-500. Most of those stories also name other compounds, especially BPC-157.
What the research says
TB-500 is a synthetic fragment based on thymosin beta-4. Animal and lab studies of thymosin beta-4 suggest roles in cell migration, blood-vessel growth and wound repair, and small human trials of thymosin beta-4 (not TB-500) have tested eye and skin wound healing. There are no published human trials of TB-500 for muscle or tendon injuries. It is not approved, and it is on the WADA prohibited list. Last reviewed: October 2026.
TB-500 reports by the numbers
There are currently 29 published confessions tagged TB-500. Each one was read and sorted by what the writer says happened. A report can sit in more than one row, and some are questions or stack lists with no outcome at all. These are counts of stories, not rates of anything.
| What the confession says | Count (mid-October read) | Examples |
|---|---|---|
| Also tagged BPC-157 | 28 | Every report except #192 |
| An injury, surgery, or long-running pain is the reason | 15 | #181, #385, #568 |
| The writer describes a person improving | 10 | #192, #281, #456 |
| No change felt | 3 | #116, #179, #745 |
| A problem the writer links to the stack | 5 | #120, #456, #482, #595, #680 |
| Given to a pet | 3 | #272, #331, #804 |
| Also tagged KPV | 5 | #272, #453, KPV hub |
| States a TB-500 amount | 2, both blends | #418, #589 |
What does TB-500 do? What people report
The reports are self-reports, and they disagree. Some describe recovery they attribute to a BPC-157 and TB-500 stack. Some describe nothing. A few describe feeling worse. None of them isolate TB-500 in a way that would let this page say what the fragment itself did.
#453 left a KPV blend at home and travelled with BPC-157 and TB-500, then felt better after going back to the full blend. #568 describes a torn meniscus: BPC-157 near the knee and in the belly, TB-500 in the belly, and says the clicking and pain eased. #192 says ten weeks of TB-500 preceded cancelling two booked shoulder surgeries. That is what the writer reports, not a result this site can verify.
TB-500 side effects users report
Read as a set, the confessions do not produce a ranked side-effect list. These are the ones that actually describe a problem, in the order they appear:
- —#456 — shoulder felt better on BPC-157 and TB-500, then repeated stomach injections caused swelling and soreness.
- —#595 — TB-500 with BPC-157 and HGH: redness in the first month, then injection-site welts and a six-day full-body hive flare. It cleared after they stopped everything.
- —#120 — five days of BPC-157 and TB-500, then bowel trouble, nausea, a panic attack, and both knees flaring. The writer is not claiming a diagnosis.
- —#482 — BPC-157, TB-500, and SS-31 "like poison." No further detail.
- —#116 and #179 — a full course, and 90 days, with no change they could feel. #179 switched sources and still felt nothing.
- —#680 — a new penile curve after several weeks of BPC-157 and TB-500. The writer says they do not know if it is related, and they are seeing a urologist.
Is TB-500 safe?
TB-500 is not approved for human use, and this set of reports is not a safety study. The same archive includes people who say a nagging injury eased and people who say they felt nothing or got worse, almost always on a stack. This page does not call it safe. If you have symptoms, talk to a clinician.
More side-effect threads: side effects and peptide side effects.
TB-500 doses in confessions: what writers reported, not a recommendation
Quoted user confessions only. The figures below are what anonymous writers said they took, copied as written. They are not verified, not a protocol, and not a recommendation. TB-500 has no approved human dose. This is not a dosing recommendation.
Most TB-500 confessions never state a dose. They say "a full course," "ten weeks," "90 days," or "several weeks." The few numbers are for blends that also contain other peptides, so they are not a TB-500 dose. #589 describes 400 mcg of a BPC / TB-500 / KPV blend, plus a separate BPC-157 injection. That is one person's blend, reported after the fact.
The only other TB-500 figure in the archive is oral, not injected. #418 says an uncle took "oral BPC/KPV/TB-500 500mcg each" twice a day on an empty stomach. That is a relative's account of someone else's protocol, again as a three-compound combination.
So the honest answer to "what TB-500 dosage do people report?" is: almost none on its own. Every number here is a blend, quoted from an anonymous confession, and none is a measured, TB-500-only dose or a protocol.
Preparation talk on the site, separate from these reports: injecting peptides and reconstituting peptides. The stack these blends come from is collected at TB-500 + BPC-157 stack, and the other compounds have their own hubs: BPC-157 and KPV.
| Report | Stated amount | Route / frequency | TB-500 alone? |
|---|---|---|---|
| #589 | 400 mcg (BPC-157 / TB-500 / KPV blend) | Injection, nightly, 50 days | No, three-compound blend |
| #418 | 500 mcg each of BPC-157, KPV, TB-500 | Oral, twice a day | No, three compounds |
This is not a dosing recommendation.
TB-500 benefits users describe
Where people describe a benefit, it is recovery: a shoulder, a meniscus, a hamstring, a post-surgery foot, a knee. The same paragraphs usually name BPC-157 as well. Hair does not come up in this set of reports, so this page does not list it as something users describe.
A benefit in a confession is the writer's account of their own body. It is not a result you should expect, and it is not separable from the rest of the stack they were on.
TB-500 + BPC-157 stack
The stack is the actual subject of most of these reports. TB-500 + BPC-157 stack collects that topic. BPC-157 vs TB-500 is the comparison thread. The BPC-157 hub is BPC-157.
Reports that felt worse (#120, #482, #595) were also stacks. Pairing the two is not described here as safer or more effective. It is described as common.
Anonymous TB-500 reports
Community Q&A
- What is TB-500?
- TB-500 is a synthetic fragment related to thymosin beta-4. It has been studied in lab and animal research on tissue repair and is not approved for human use. The confessions tagged with it are mostly injury stories, and most of them also mention BPC-157.
- What does TB-500 do, according to users?
- Users do not agree. Some describe less pain or an easier recovery while taking TB-500 with BPC-157. Others describe no change after weeks or months. These are self-reports, often of several compounds at once, not evidence that TB-500 caused the change.
- What are the reported side effects of TB-500?
- In this archive: stomach-injection swelling (#456), welts and hives in a stack that also included BPC-157 and HGH (#595), and one short course followed by nausea, bowel trouble, panic, and knee flares (#120). Other people report no effect at all. One writer mentions a new penile curve and says they do not know if it is related (#680).
- Is TB-500 safe?
- It is not approved for human use. The reports include both recovery stories and accounts of feeling worse or nothing. This page does not make a safety claim. Talk to a clinician about symptoms.
- Is TB-500 the same as thymosin beta-4?
- No. TB-500 is a short synthetic fragment based on the active region of thymosin beta-4, a natural 43-amino-acid protein. Most research is on thymosin beta-4 in animals, not on TB-500 in people. TB-500 is not an approved drug and is on the WADA prohibited list.
- Is there a standard TB-500 dosage?
- Not on this site. TB-500 is not approved for human use, so there is no approved dose, and the confessions do not converge on one. This page only quotes what writers said they took. It is not a dosing recommendation.
- What is TB-500 used for?
- In these confessions, injury and recovery: shoulders, knees, a meniscus, a hamstring, a foot after surgery. People almost always mention it next to BPC-157 rather than on its own.
- How many TB-500 reports say it worked?
- In a mid-October read of the published TB-500 confessions, 10 describe a person improving, 3 describe no change, and 5 describe a problem the writer connects to the stack. The rest are questions, stack lists, or pet stories. 28 of the current 29 also name BPC-157, so none of these isolate TB-500.
- Do people take TB-500 on its own?
- Almost never in this archive. One report (#192) names TB-500 alone: ten weeks, then two booked shoulder surgeries cancelled. The other 28 also name BPC-157, and several add KPV, GHK-Cu, or a GLP-1.
- Is TB-500 the same as thymosin beta-4?
- No. TB-500 is a synthetic fragment related to thymosin beta-4, not the full protein. The site keeps a separate thymosin beta-4 page for reports that use that name.
- TB-500 vs BPC-157: what's the difference?
- The confessions rarely separate them. Writers describe taking both and then attribute whatever they felt to the pair. The site's BPC-157 vs TB-500 topic is where the comparison is collected. This page does not claim one is better.
- How long does TB-500 take to work?
- There are no human trials, so there is no evidence-based timeline. Writers' reported timelines vary and are often confounded by rest, physiotherapy and other compounds.
- How does TB-500 make you feel?
- Most writers describe no immediate feeling; some report tiredness, headache or injection-site irritation. These are anecdotal reports, not trial data.
Anonymous first-hand reports plus sourced context — educational only, not medical advice. Editorial policy & corrections.