Melanotan 1: The Approved Drug vs the Tanning Injection
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Anonymous user report. Not medical advice. Peptides discussed are not FDA-approved for the uses described. Editorial process →
What is Melanotan 1?
Melanotan 1 is the research name for afamelanotide, a synthetic analogue of alpha-MSH that stimulates melanin production. As the implant Scenesse, it was FDA approved in October 2019 to increase pain-free light exposure in adults with erythropoietic protoporphyria, a rare disorder causing painful reactions to light. Online "Melanotan 1" injections sold for tanning are unregulated and are not the approved product (afamelanotide, Melanotan 2).
Evidence and risks
In trials for the approved use, common side effects included implant-site reactions, nausea, headache and skin darkening; the label advises regular skin examinations because it darkens existing moles. Dermatologists and regulators in several countries have warned that unregulated tanning injections may cause changing moles, nausea and flushing, and that the products' contents are unknown. A tan does not replace sun protection. Last reviewed: October 2026.
Anonymous Melanotan 1 reports
No reports found.
If you have used Melanotan 1, submit what happened.
Submit yoursCommunity Q&A
- Is Melanotan 1 FDA approved?
- Afamelanotide is approved as the Scenesse implant only for erythropoietic protoporphyria. Tanning injections sold online are not approved.
- What is the difference between Melanotan 1 and 2?
- Melanotan 1 (afamelanotide) is more selective for pigmentation; Melanotan 2 also affects appetite and sexual arousal and is not approved for any use.
- Does Melanotan 1 affect moles?
- It can darken existing moles and freckles, which is why the approved label advises regular skin examinations.
Anonymous first-hand reports plus sourced context — educational only, not medical advice. Editorial policy & corrections.