Canada \u00b7 PT-141
PT-141 (Vyleesi) in Canada: legal status and user reports.
Short answer
Bremelanotide is approved in the US as Vyleesi, but it has no listing in Health Canada's Drug Product Database, so there is no authorized product in Canada. "Research" PT-141 sold online is unauthorized; Health Canada's advisory warns such products can be contaminated or mislabelled. More: are peptides legal in Canada?
Risks
Nausea, flushing, headache and a temporary blood-pressure rise are the labelled effects of the approved US product; repeated use can darken skin. See PT-141 side effects.
What PT-141 users report
Our live tally is temporarily unavailable. See the full PT-141 hub.
PT-141 and the alternatives
Status in Canada and the US.
| Product | What it is | Canada | US |
|---|---|---|---|
| Vyleesi (bremelanotide) | Melanocortin agonist injection, as needed | Not authorized | FDA approved June 2019 for low sexual desire in premenopausal women |
| Addyi (flibanserin) | Daily tablet | Authorized | Approved |
| “Research” PT-141 | Unregulated vials, nasal sprays | Unauthorized | Not approved |
| Melanotan II | Related tanning peptide | Unauthorized | Not approved |
In the RECONNECT trials behind Vyleesi's approval, improvements in desire and distress were modest, and about 40% had nausea. It also darkened skin or gums in some users.
Last reviewed October 15, 2026against Health Canada's Drug Product Database and Health Canada DPD and FDA.
What people with low desire can do in Canada
- Talk to a family doctor or gynecologist: low desire can be linked to medicines (such as some antidepressants), hormones, relationships, mood or pain.
- Addyi (flibanserin) is an authorized prescription option for some premenopausal women.
- Sex therapy and counselling have evidence for distress about desire.
- For erectile dysfunction, authorized options include sildenafil and tadalafil; PT-141 is not authorized for men in Canada.
- Avoid research PT-141 or nasal sprays bought online: they are unauthorized, and nausea, flushing and blood-pressure rises are reported.
Related
Frequently asked questions
- Is PT-141 used for men?
- It has been studied for erectile dysfunction, but no product is authorized for men in Canada or the US.
- How well does bremelanotide work?
- In the RECONNECT trials, improvements in desire and related distress were modest compared with placebo.
- Is Vyleesi available in Canada?
- No. Vyleesi (bremelanotide) is FDA-approved in the US but has no listing in Health Canada's Drug Product Database as of October 2026.
- Is PT-141 legal in Canada?
- PT-141 sold online as a research peptide is not an authorized drug in Canada, so it cannot legally be sold for human use. Health Canada has warned about unauthorized injectable peptides bought online.
- What is authorized in Canada for low sexual desire in women?
- Addyi (flibanserin), an oral tablet, received Health Canada authorization in 2018. Talk to a clinician about options.
- What are PT-141 side effects?
- In US trials of Vyleesi, nausea affected about 40%; flushing, headache and a temporary rise in blood pressure were also seen.
Sources
General information only — not medical, legal or regulatory advice. Peptide Confessions does not sell, source or recommend any product or vendor, and nothing here is dosing guidance. Speak with a licensed Canadian healthcare professional or pharmacist about any medication. Editorial process →