Tesamorelin vs Sermorelin

Short answer

Both are GHRH analogues that prompt the pituitary to release growth hormone. Tesamorelin is a stabilised, longer-acting version approved in the US (Egrifta) only for visceral fat in HIV-associated lipodystrophy. Sermorelin is the shorter original fragment, once approved for children and now mostly compounded. Neither is approved for general fat loss or anti-aging. See sermorelin and ipamorelin vs sermorelin. No dose is listed here.

What is the difference between tesamorelin and sermorelin?

Both are synthetic peptides in the growth hormone-releasing hormone (GHRH) family. They are not the same molecule.

Tesamorelin is a modified GHRH analogue. In the US it is approved as Egrifta for visceral fat in HIV-associated lipodystrophy. That label is not a general fat-loss indication, and it is not a suggestion to take it.

Sermorelin is a synthetic copy of the first 29 amino acids of GHRH. It has been used to test whether the pituitary releases growth hormone. That is a description of the molecule.

Educational page. Anonymous reports, not medical advice, and not a dosing guide.

Tesamorelin vs sermorelin, side by side

The table is the class of each molecule and where the reports live. It is not a ranking, and it is not a result.

What users report about tesamorelin

These are personal accounts on the tesamorelin page. They do not line up into one outcome.

Waist comes up more than the scale. #81 says two inches off the waist in eight weeks with no scale change, and frames tesamorelin as visceral fat rather than weight. #295 says the same shape of result: no pounds, two inches, and tells the reader to use a tape. #211 got on it for belly fat and calls that part slow. #591 describes a visible abdominal change over about eight weeks and says they were not in a gym. That is one story.

Allergic reactions are in the file, and they are not a footnote. #107 describes anaphylaxis on a first injection. #183 describes anaphylaxis and says they continued. #576 describes a histamine reaction after three months, on a new vial. #658 liked a tesamorelin/ipamorelin recomp, then developed an allergy and stopped.

#380 stopped after the first week: tingling, almost no food, vomiting. #387 says the stomach looked worse before it looked better. #634 describes joint pain and skin sensitivity after an accidental double dose of tesamorelin with ipamorelin. #746 describes a hospital stay and a reactive-hypoglycemia diagnosis after tesamorelin and ipamorelin, a fasted workout, and a large breakfast.

#542 has not taken tesamorelin. The note is someone deciding whether to try it for belly fat after a CJC-1295/ipamorelin run.

What users report about sermorelin

The sermorelin page has four confessions. They do not describe one shared result.

Sleep comes up once. #119 calls sermorelin "my sleep and my HGH hit in one," inside a stack that also includes retatrutide and epitalon. The weight comment in that confession is about retatrutide.

The only side effect named is injection sting. #204 is a first injection: cold liquid, shaking hands, and a question about whether the sting means the mix was wrong.

#685 is four months in. The confession is about liking the bedtime injection routine, not a measured result. Hunger does not come up. Muscle gain does not come up. With four reports, absence is the finding.

Has anyone here compared them directly?

This comparison topic has no posts tagged to it. One confession names both compounds. #571 lists tesamorelin and sermorelin among several peptides over four months and says the only noticeable effect was from CJC-1295. It does not say which GHRH peptide was stronger.

Anything stronger than that — a potency ranking, a fat-loss winner, a stacking recipe — is not in these reports. Related pages: tesamorelin vs CJC-1295, CJC-1295 vs sermorelin, and ipamorelin vs sermorelin.