No VIP product is approved in the US or Canada. Aviptadil-based products are approved for erectile dysfunction in some other countries.

Does VIP nasal spray help mould illness?

Evidence comes from uncontrolled case series; there are no controlled trials.

What is VIP peptide used for?

Research and some clinics explore it for pulmonary, inflammatory and CIRS-related conditions. It is not FDA-approved for those uses.

What are VIP side effects?

Known effects of VIP activity include flushing, low blood pressure, fast heart rate and diarrhoea.

VIP Peptide: What 1 User Reports

1 anonymous report

Peptides for Inflammation Peptides for Immune System Thymosin Peptides

Also known as:

vasoactive intestinal peptideaviptadil

often mentioned with:

BPC-157 GHK-Cu TB-500 KPV Thymosin Alpha-1

What is VIP?

Vasoactive intestinal peptide (VIP) is a natural 28-amino-acid neuropeptide that relaxes smooth muscle, widens blood vessels and modulates immune signalling. A synthetic version, aviptadil, has been studied for pulmonary hypertension and was tested in COVID-19 respiratory failure without winning FDA approval. VIP also features in some functional-medicine protocols for mould-related illness (CIRS), where evidence is limited. Flushing, low blood pressure and diarrhoea are known effects of VIP activity. Peptide Confessions does not publish dosing, timing, injection or sourcing guidance.

VIP research at a glance

Last reviewed October 15, 2026.

Use	What was studied	Result
Pulmonary hypertension	Inhaled aviptadil, small studies	Early signals; not approved
COVID-19 respiratory failure	IV and inhaled aviptadil trials	Did not win FDA authorization; main trials missed their goals
Erectile dysfunction	Aviptadil with phentolamine injected into the penis	Approved in some countries outside North America
Mould illness (CIRS)	Nasal VIP in uncontrolled case series	No controlled trials

Side effects and risks

Because VIP widens blood vessels and acts on the gut, flushing, low blood pressure, a fast heartbeat and watery diarrhoea are the expected effects; VIP-secreting tumours (VIPomas) cause severe diarrhoea through the same pathway. Compounded nasal sprays vary in quality and are not approved. See peptides for inflammation.

What users report

Tagged confessions include #331. The file is thin; one account is not evidence of benefit.

Anonymous VIP reports

My 11-year-old pitbull was done. 30 pounds overweight, crippled by arthritis and constant inflammation. Vets basically shrugged — “make her lose weight and here’s more meds.” We tried diet after diet until one finally clicked. She dropped all 30 pounds, but she still barely moved. Just enough to eat and do her business. The pain in her eyes was heartbreaking. She looked miserable. Desperate, I started her on BPC-157 and TB-500. Within two weeks she was already moving better — actually getting up without struggling. Now she’s on Wolverine+ and VIP and it’s like she’s a different dog. She’s happy again. She’s walking all over the yard, sunbathing like she owns the place, and has that spark back in her eyes. She’s not 100% yet and still has some room to improve, but she has a whole new lease on life. Peptide research for pets is 100% legit. Vets won’t touch it, but it gave my girl her joy back when nothing else worked

#331

Sourcing

If you have used VIP, submit what changed — or did not.

Submit yours

Community Q&A

Is VIP approved?: No VIP product is approved in the US or Canada. Aviptadil-based products are approved for erectile dysfunction in some other countries.
Does VIP nasal spray help mould illness?: Evidence comes from uncontrolled case series; there are no controlled trials.
What is VIP peptide used for?: Research and some clinics explore it for pulmonary, inflammatory and CIRS-related conditions. It is not FDA-approved for those uses.
What are VIP side effects?: Known effects of VIP activity include flushing, low blood pressure, fast heart rate and diarrhoea.
Does this page give dosing advice?: Peptide Confessions does not publish dosing, timing, injection or sourcing guidance.

Anonymous first-hand reports plus sourced context — educational only, not medical advice. Editorial policy & corrections.