SS-31 Peptide: What 17 Users Report
Mitochondria-targeting peptide that concentrates in the inner mitochondrial membrane. Studied for protection against oxidative stress and aging.
Also known as:
often mentioned with:
community guides:
Related mitochondrial peptides:
Anonymous user report. Not medical advice. Peptides discussed are not FDA-approved for the uses described. Editorial process →
What is the SS-31 peptide?
SS-31 (also called elamipretide, or MTP-131) is a lab-made peptide that concentrates in the inner mitochondrial membrane. It is not an approved drug.
That is the compound. Everything after it is what the published confessions say. Most of them also name other peptides, especially MOTS-c.
What do people report SS-31 doing?
They do not report one effect. Energy is the reason several people give for taking it, and it is not a shared result.
#476 calls 2 mg a day for energy a game changer. #631 uses the same figure and says it matters if you need the energy, and will not do much if you already have it. #110 calls SS-31 the odd one in a long stack: the closest thing to the lights coming on, with shorter recovery between hard sessions.
Other energy notes are stacked, so they are not an SS-31 result. #673 added MOTS-c and SS-31 together and describes energy as through the roof, and no side effects of any kind, after a long GLP-1 stretch. #678 finished an SS-31 cycle, started MOTS-c, and felt more energetic in the afternoon.
The file also contains the opposite. #643 tried SS-31 for fatigue after sepsis and got more tired. An earlier course went the same way, then about three good days after it stopped. #645 is also taking SS-31 and, months later, finds no obvious change in endurance or recovery between sets.
#764 is not an energy story. Smells had registered as the same thing for almost six years. In the second week of SS-31, the writer says they could tell them apart again. #106 says SS-31 helped with headaches after a spinal injury. That is the writer's account. This page cannot check it.
SS-31 side effects reported by users
The reports that describe a problem, rather than a benefit or a non-event:
- —#643 — more tired, on a course taken for fatigue. Three unusually good days came after an earlier course stopped, not during it.
- —#482 — BPC-157, TB-500, and SS-31 "like poison." No further detail. The other two compounds are in the same sentence.
- —#645 — no obvious change in endurance or between-set recovery. The writer is on SS-31 and MOTS-c.
Is SS-31 safe?
SS-31 is not an approved drug, and these confessions are not a safety study. The same archive has an energy story, a smell story, a person who got more tired, and a stack someone called poison. This page does not call it safe. If you have symptoms, talk to a clinician.
SS-31 dosage: what people report
Two confessions state a number, and it is the same number. #476 and #631 both say 2 mg a day, both about energy. Nobody else here states an SS-31 dose, a schedule, or a cycle length in figures.
#815 mentions four weeks of SS-31, then asks about MOTS-c amounts. Those microgram figures are about MOTS-c, not SS-31. #689 injected the wrong vial — CJC-1295/ipamorelin, mistaken for SS-31 — and describes flushing, a faster heart rate, and hunger. That is not an SS-31 dose, and it is not an SS-31 effect.
This is not a dosing recommendation.
SS-31 timeline: when people say they noticed something
The only clock that is both specific and about SS-31 alone is #764: smell returning in the second week. #815 had been on SS-31 for four weeks before starting MOTS-c, and does not describe an SS-31 result. #643 felt worse during the course, then had three good days after an earlier course stopped. #645 is still looking months later and does not see an endurance change.
The energy reports do not give a day count. There is no shared timeline on this page.
SS-31 stacks, and how it sits next to MOTS-c
SS-31 rarely shows up alone. The pair people actually write down is SS-31 and MOTS-c. #678 and #815 run SS-31 first and MOTS-c after. #673 added both at once. #645 is on both and does not see a workout difference. These are sequence notes, not a head-to-head.
Other names in the same confessions: retatrutide, tirzepatide, BPC-157, TB-500 (#482), NAD+, semax, and selank (#403). #110 keeps GHK-Cu and SS-31 in one stack and describes them as different jobs.
More on the longevity framing: peptides for longevity. Side-effect threads that are not limited to SS-31: peptide side effects.
more topics on these reports:
Anonymous SS-31 reports
Im a peptide fanatic. Two years deep in peptides. Honest notes, just what each actually does in my body. CJC-1295 with Ipamorelin is my sleep fix. Used to wake five times a night, now I'm out cold till morning. GHK-Cu I'll never drop. Tore my forearm open on a bike chain last summer and it closed clean enough to surprise the urgent care guy. SS-31 is the weird one. Closest thing to the lights coming on, and my recovery between hard sessions got noticeably shorter. Semax flips my focus to overdrive. Great for deadlines, useless past early afternoon or I can't sleep. Tirzepatide slowed my gut so much I had to move my night supplements earlier, they just sit there otherwise. BPC-157 is the quiet one for joints and gut. I only notice it when I run out. Thing nobody warns you about with almost all of them: water weight. I'll wake up 5 pounds up and it's pure sodium, not fat. Took me way too long to stop letting the scale wreck my morning.
#110Community Q&A
- What is the SS-31 peptide?
- SS-31 (elamipretide, MTP-131) is a lab-made peptide that concentrates in the inner mitochondrial membrane. It is not an approved drug. The confessions tagged with it are mostly energy and recovery notes, and most of them also name other compounds.
- What does the SS-31 peptide do, according to users?
- Users do not agree. Some describe more energy or shorter recovery between hard sessions (#476, #631, #110). One person says a long-lost sense of smell returned in the second week (#764). Others describe getting more tired (#643) or no change in endurance (#645). Several of the energy notes also include MOTS-c. These are personal accounts, not evidence.
- What SS-31 dosage do people report?
- Two reports state 2 mg a day, both in the context of energy (#476, #631). No other published SS-31 confession here gives a number. A separate note about flushing was a CJC-1295/ipamorelin vial injected by mistake (#689), not an SS-31 dose. That is not a dosing recommendation.
- What side effects do people report with SS-31?
- In this archive: more fatigue on a course taken for fatigue (#643), and one stack of BPC-157, TB-500, and SS-31 that the writer called poison (#482). Another person on SS-31 and MOTS-c reports no endurance change (#645). There is no ranked side-effect list.
- How long does SS-31 take to notice?
- There is no shared timeline. The specific SS-31-only clock in these reports is a change in smell in the second week (#764). One person felt worse on the course and described three good days after stopping an earlier one (#643). Months on SS-31 plus MOTS-c produced no obvious endurance change for someone else (#645).
- How do people report stacking SS-31 with MOTS-c?
- Often, and not as a comparison. Some finish an SS-31 stretch and then start MOTS-c (#678, #815). One person added both at once and describes high energy (#673). One person is on both and sees no workout difference (#645). The MOTS-c hub is the page for that compound.
- Is the SS-31 peptide safe?
- This page does not say. It is not an approved drug, and the reports point in more than one direction. Talk to a clinician about symptoms. Two energy stories and one fatigue story are not a safety review.
Anonymous first-hand reports plus sourced context — educational only, not medical advice. Editorial policy & corrections.