Ghrelin
Endogenous 28-amino acid peptide produced primarily in the stomach. The natural ligand for GHS-R1a receptors; regulates hunger, GH secretion, and energy homeostasis.
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Also known as:
growth hormone releasing peptide endogenousghrl
community guides:
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Community Q&A
- What does ghrelin do in the body?
- Community accounts discussing ghrelin appear primarily in the context of GH secretagogues — explaining why GHRP-6, ipamorelin, and MK-677 produce hunger (they act on the same receptor). Ghrelin itself rarely appears as a compound being used directly in confessions; its relevance in the community is as the endogenous template for the GHRP class. Accounts describing post-bariatric surgery discuss reduced ghrelin as the mechanism behind long-term appetite suppression.
- Does using GH secretagogues increase ghrelin?
- Community accounts consistently describe GHRP-class compounds as ghrelin mimetics — producing hunger by acting on the same receptor (GHS-R1a) rather than by increasing ghrelin itself. GHRP-6 accounts describe the most intense hunger effect because of its strong ghrelin receptor affinity; ipamorelin accounts describe minimal hunger because of its cleaner selectivity profile. Understanding this distinction appears frequently in community explanations of why different secretagogues produce different appetite effects.